Acted in television commercials as a baby.
1980 TV-movie debut in "Bogie" (CBS); played Leslie Bogart as a child.
1980 Made first film appearance in a bit part in "Altered States".
1982 Played Gertie, the younger sister, in "E.T., The Extra-Terrestrial".
1984 Starting drinking at age nine (date approximate).
1984 Played the title character in the sci-fi thriller "Firestarter".
1984 Starred as a young girl divorcing her parents in "Irreconcilable Differences".
1985 Started smoking marijuana (date approximate).
1986 Starred in the NBC TV remake of "Babes in Toyland".
1987 Began abusing cocaine (date approximate).
1989 Institutionalized in a rehab center-cum-mental institution after a failed suicide attempt (date approximate).
Lived with musician and recovering addict David Crosby and his wife Jan for close to a year after her treatment.
1990 At age 15, filed papers to become legally emancipated from her parents in order to work the same hours as 18-year-olds (date approximate).
1991 Lived with film director Tamra Davis and her husband briefly.
1992 First starring film role, in "Poison Ivy".
1992 TV series debut as regular, had featured role in the short-lived summer serial "2000 Malibu Road" (CBS).
1992 Directed by Davis in "Guncrazy" (shown at film festivals before airing on Showtime prior to its 1993 theatrical release).
1993 Played 'Long Island Lolita' Amy Fisher in the ABC TV-movie, "The Amy Fisher Story".
1994 Founded the production company, Flower Films, Inc.
1995 Cast as the flirtatious Holly in "Boys on the Side", also featuring Whoopi Goldberg and Mary-Louise Parker.
1995 Starred opposite Chris O'Donnell as his free-spirited, mentally ill romantic interest in "Mad Love".
1996 Made cameo appearance as a high school student targeted by the killer in "Scream".
1996 Played featured role as Edward Norton's fiancee in Woody Allen's "Everyone Says I Love You"; had singing voice dubbed.
1998 Starred opposite Adam Sandler in the popular romantic comedy "The Wedding Singer".
1998 Played a character based on Cinderella in the romance "Ever After".
1999 Starred as an awkward twentysomething reporter who returns to high school for an undercover assignment in the romantic comedy "Never Been Kissed".
2000 Co-starred with Cameron Diaz in big screen version of the 1970s TV series "Charlie's Angels".
2001 Executive produced and played supporting role of an English teacher in the critically acclaimed film "Donnie Darko"; screened at Sundance.
2001 Had leading role of a woman who got pregnant as a teenager and then raised her son as a single mom in "Riding in Cars With Boys", directed by Penny Marshall; also executive produced.
2002 Played female lead in "Confessions of a Dangerous Mind" , directed by George Clooney.
2003 Reprised role in "Charlie's Angels: Full Throttle"; made under her production banner, Flower Films.
2003 Starred opposite Ben Stiller in "The Duplex".
2004 Reunites with Adam Sandler for the comedy "50 First Dates," Barrymore plays a chronic amnesiac whom Sandler's character must woo every day.